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Article

Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration.

The Journal of clinical investigation - 1 Dec 2016

Zhang Lijuan, Du Jianhai, Justus Sally, Hsu Chun-Wei, Bonet-Ponce Luis, Wu Wen-Hsuan, Tsai Yi-Ting, Wu Wei-Pu, Jia Yading, Duong Jimmy K, Mahajan Vinit B, Lin Chyuan-Sheng, Wang Shuang, Hurley James B, Tsang Stephen H

Abstract excerpt

Retinitis pigmentosa (RP) encompasses a diverse group of Mendelian disorders leading to progressive degeneration of rods and then cones. For reasons that remain unclear, diseased RP photoreceptors begin to deteriorate, eventually leading to cell death and, consequently, loss of vision. Here, we have hypothesized that RP associated with mutations in phosphodiesterase-6 (PDE6) provokes a metabolic aberration in rod...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclic Nucleotide Phosphodiesterases, Type 6

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Source

Open in PubMed Open full text

Identifiers

PMID: 27841758
DOI: 10.1172/JCI86905
PMCID: PMC5127684

Genes

SIRT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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