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Article

Removal of phosphorylation sites of gamma subunit of phosphodiesterase 6 alters rod light response.

The Journal of physiology - 1 Mar 2007

Tsang S H, Woodruff M L, Janisch Kerstin M, Cilluffo M C, Farber D B, Fain G L

Abstract excerpt

The phosphodiesterase 6 gamma (PDE6 gamma) inhibitory subunit of the rod PDE6 effector enzyme plays a central role in the turning on and off of the visual transduction cascade, since binding of PDE6 gamma to the transducin alpha subunit (T alpha) initiates the hydrolysis of the second messenger cGMP, and PDE6 gamma in association with RGS9-1 and the other GAP complex proteins (G beta 5, R9AP) accelerates the...

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Source

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Identifiers

PMID: 17138607
DOI: 10.1113/jphysiol.2006.121772
PMCID: PMC2075409

Genes

RGS9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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