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Article

Reconstitution of the phosphodiesterase 6 maturation process important for photoreceptor cell function.

The Journal of biological chemistry - 1 Jan 2024

Singh Sneha, Srivastava Dhiraj, Boyd Kimberly, Artemyev Nikolai O

Abstract excerpt

The sixth family phosphodiesterases (PDE6) are principal effector enzymes of the phototransduction cascade in rods and cones. Maturation of nascent PDE6 protein into a functional enzyme relies on a coordinated action of ubiquitous chaperone HSP90, its specialized cochaperone aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), and the regulatory Pγ-subunit of PDE6. Deficits in PDE6 maturation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclic Nucleotide Phosphodiesterases, Type 6

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Source

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Identifiers

PMID: 38110033
DOI: 10.1016/j.jbc.2023.105576
PMCID: PMC10819763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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