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Article

Functional asymmetry and essential structural roles of PDE6α and PDE6β subunits in rod-photoreceptor integrity.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2026

Smidak Roman, Poria Deepak, Gao Fangyuan, Dong Zhiqian, Zhang Jianye, Bassetto Marco, Risaliti Eleonora, Tworak Aleksander, Liu Weijing, Kefalov Vladimir J, Palczewski Krzysztof

Abstract excerpt

Tetrameric rod phosphodiesterase-6 (PDE6), comprised of an α/β heterodimeric catalytic core and two inhibitory γ subunits, critically regulates cyclic GMP (cGMP) levels in rod photoreceptors. While the rod-PDE6 catalytic core is a heterodimer, the cone isoform is an α'/α' homodimer. This structural difference suggests a unique role for each rod subunit. Due to the lack of heterologous expression systems, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42258712
DOI: 10.1073/pnas.2604088123
PMCID: PMC13273274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Functional asymmetry and essential structural roles of PDE6α and PDE6β subunits in rod-photoreceptor integrity.PMID 42258712Read ↗

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