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Article

Molecular Characterization of a Third Member of the Guanylyl Cyclase-activating Protein Subfamily

1 Mar 1999

Abstract excerpt

The mammalian retina contains at least two guanylyl cyclases (GC1 and GC2) and two guanylyl cyclase-activating proteins (GCAP1 and GCAP2). Here we present evidence of the presence of a new photoreceptor-specific GCAP, termed GCAP3, which is closely related to GCAP1. The sequence similarity of GCAP3 with GCAP1 and GCAP2 is 57 and 49%, respectively. Recombinant GCAP3 and GCAP2 stimulate GC1 and GC2 in low...

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PMID: 10037746
DOI: 10.1074/jbc.274.10.6526

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