Article
A mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafish.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Dec 2007
Stearns George, Evangelista Meradelfa, Fadool James M, Brockerhoff Susan E
Abstract excerpt
Photoreceptor degeneration is a common cause of inherited blindness worldwide. We have identified a blind zebrafish mutant with rapid degeneration of cone photoreceptors caused by a mutation in the cone phosphodiesterase c (pde6c) gene, a key regulatory component in cone phototransduction. Some rods also degenerate, primarily in areas with a low density of rods. Rod photoreceptors in areas of the retina that...
Topics
- Animals
- Cell Count
- Cyclic Nucleotide Phosphodiesterases, Type 6
- Disease Models, Animal
- Disease Progression
- Electroretinography
- Genes, Recessive
- Mutation
- Retinal Cone Photoreceptor Cells
- Retinal Degeneration