Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Self-renewal and cancer of the gut: two sides of a coin.

Science (New York, N.Y.) - 25 Mar 2005

Radtke Freddy, Clevers Hans

Abstract excerpt

The intestinal epithelium follows the paradigms of stem cell biology established for other self-renewing tissues. With a unique topology, it constitutes a two-dimensional structure folded into valleys and hills: the proliferative crypts and the differentiated villi. Its unprecedented self-renewal rate appears reflected in a high susceptibility to malignant transformation. The molecular mechanisms that control...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to Bone Morphogenetic Proteins
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Helix-Loop-Helix Motifs

Share to Intercellular Signaling Peptides and Proteins

Share to Intestinal Mucosa

Share to Receptors, Notch

Share to Wnt Proteins

Source

Identifiers

PMID: 15790842
DOI: 10.1126/science.1104815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Self-renewal and cancer of the gut: two sides of a coin.PMID 15790842Read ↗

Wnt signaling in the intestinal epithelium: from endoderm to cancer.Semantic proximity Read ↗

Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colonSemantic proximity Read ↗

Mini-Gut Organoids: Reconstitution of the Stem Cell NicheSemantic proximity Read ↗

Gut microbiota‐stem cell niche crosstalk: A new territory for maintaining intestinal homeostasisSemantic proximity Read ↗

Gut stem cells in tissue renewal and disease: methods, markers, and mythsSemantic proximity Read ↗

Wnt signaling in adult intestinal stem cells and cancerSemantic proximity Read ↗

The intestinal stem cell as a target: A reviewSemantic proximity Read ↗

Live and let die in the intestinal epithelium.Semantic proximity Read ↗

Defining a stem cell hierarchy in the intestine: markers, caveats and controversiesSemantic proximity Read ↗

Mammalian Intestinal Development and Differentiation—The State of the ArtSemantic proximity Read ↗

Intestinal stem cells and the colorectal cancer microenvironment.Semantic proximity Read ↗

Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epitheliumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.