Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer

10 Feb 2010

Abstract excerpt

NOTCH signaling is critical for specifying the intestinal epithelial cell lineage and for initiating colorectal adenomas and colorectal cancers (CRC). Based on evidence that NOTCH is important for the maintenance and self-renewal of cancer-initiating cells in other malignancies, we studied the role of NOTCH signaling in colon cancer-initiating cells (CCIC). Tumors formed by CCICs maintain many properties of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Digestive system and related health
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20145124
DOI: 10.1158/0008-5472.can-09-2557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon CancerPMID 20145124Read ↗

Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colonSemantic proximity Read ↗

Signaling in colon cancer stem cellsSemantic proximity Read ↗

Downregulation of Enteroendocrine Genes Predicts Survival in Colon Cancer: A Bioinformatics-Based AnalysisSemantic proximity Read ↗

A Review on Notch Signaling and Colorectal Cancer.Semantic proximity Read ↗

Self-renewal and cancer of the gut: two sides of a coin.Semantic proximity Read ↗

The intestinal stem cell as a target: A reviewSemantic proximity Read ↗

Identification, isolation and characterization of human LGR5-positive colon adenoma cellsSemantic proximity Read ↗

Pleiotropic effects of DCLK1 in cancer and cancer stem cellsSemantic proximity Read ↗

CUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancerSemantic proximity Read ↗

Nodal Promotes the Self-Renewal of Human Colon Cancer Stem Cells via an Autocrine Manner through Smad2/3 Signaling PathwaySemantic proximity Read ↗

Dedifferentiation-Driven Oncogenic Stemness Promotes Tumor-Sustaining Adaptability in the Intestinal EpitheliumSemantic proximity Read ↗

SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut EpitheliumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.