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Wnt signaling in adult intestinal stem cells and cancer

2 Dec 2013

Abstract excerpt

Signaling initiated by secreted glycoproteins of the Wnt family regulates many aspects of embryonic development and it is involved in homeostasis of adult tissues. In the gastrointestinal (GI) tract the Wnt pathway maintains the self-renewal capacity of epithelial stem cells. The stem cell attributes are conferred by mutual interactions of the stem cell with its local microenvironment, the stem cell niche. The...

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PMID: 24308963
DOI: 10.1016/j.cellsig.2013.11.032

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