Article
A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts.
Gut - 1 Jan 2013
Leedham Simon J, Rodenas-Cuadrado Pedro, Howarth Kimberley, Lewis Annabelle, Mallappa Sreelakshmi, Segditsas Stefania, Davis Hayley, Jeffery Rosemary, Rodriguez-Justo Manuel, Keshav Satish, Travis Simon P L, Graham Trevor A, East James, Clark Susan, Tomlinson Ian P M
Abstract excerpt
OBJECTIVE: Wnt signalling is critical for normal intestinal development and homeostasis. Wnt dysregulation occurs in almost all human and murine intestinal tumours and an optimal but not excessive level of Wnt activation is considered favourable for tumourigenesis. The authors assessed effects of pan-intestinal Wnt activation on tissue homeostasis, taking into account underlying physiological Wnt activity and...
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