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Article

Wnt signaling in the intestinal epithelium: from endoderm to cancer.

Genes & development - 15 Apr 2005

Gregorieff Alex, Clevers Hans

Abstract excerpt

The Wnt pathway controls cell fate during embryonic development. It also persists as a key regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational deregulation of the Wnt cascade is closely associated with malignant transformation. The intestinal epithelium represents the best-understood example for the closely linked roles of Wnt signaling in homeostatic self-renewal and malignant...

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Identifiers

PMID: 15833914
DOI: 10.1101/gad.1295405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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