Article
Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression.
PLoS genetics - 1 Jan 2013
Sakurai Daisuke, Zhao Jian, Deng Yun, Kelly Jennifer A, Brown Elizabeth E, Harley John B, Bae Sang-Cheol, Alarcόn-Riquelme Marta E, Edberg Jeffrey C, Kimberly Robert P, Ramsey-Goldman Rosalind, Petri Michelle A, Reveille John D, Vilá Luis M, Alarcón Graciela S, Kaufman Kenneth M, Vyse Timothy J, Jacob Chaim O, Gaffney Patrick M, Sivils Kathy Moser, James Judith A, Kamen Diane L, Gilkeson Gary S, Niewold Timothy B, Merrill Joan T, Scofield R Hal, Criswell Lindsey A, Stevens Anne M, Boackle Susan A, Kim Jae-Hoon, Choi Jiyoung, Pons-Estel Bernardo A, Freedman Barry I, Anaya Juan-Manuel, Martin Javier, Yu C Yung, Chang Deh-Ming, Song Yeong Wook, Langefeld Carl D, Chen Weiling, Grossman Jennifer M, Cantor Rita M, Hahn Bevra H, Tsao Betty P
Abstract excerpt
Immunoregulatory cytokine interleukin-10 (IL-10) is elevated in sera from patients with systemic lupus erythematosus (SLE) correlating with disease activity. The established association of IL10 with SLE and other autoimmune diseases led us to fine map causal variant(s) and to explore underlying mechanisms. We assessed 19 tag SNPs, covering the IL10 gene cluster including IL19, IL20 and IL24, for association with...
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