Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression.

doi:10.1016/j.ajhg.2015.03.002

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Article

Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression.

American journal of human genetics - 7 May 2015

Lu Xiaoming, Zoller Erin E, Weirauch Matthew T, Wu Zhiguo, Namjou Bahram, Williams Adrienne H, Ziegler Julie T, Comeau Mary E, Marion Miranda C, Glenn Stuart B, Adler Adam, Shen Nan, Nath Swapan K, Stevens Anne M, Freedman Barry I, Tsao Betty P, Jacob Chaim O, Kamen Diane L, Brown Elizabeth E, Gilkeson Gary S, Alarcón Graciela S, Reveille John D, Anaya Juan-Manuel, James Judith A, Sivils Kathy L, Criswell Lindsey A, Vilá Luis M, Alarcón-Riquelme Marta E, Petri Michelle, Scofield R Hal, Kimberly Robert P, Ramsey-Goldman Rosalind, Joo Young Bin, Choi Jeongim, Bae Sang-Cheol, Boackle Susan A, Graham Deborah Cunninghame, Vyse Timothy J, Guthridge Joel M, Gaffney Patrick M, Langefeld Carl D, Kelly Jennifer A, Greis Kenneth D, Kaufman Kenneth M, Harley John B, Kottyan Leah C

Abstract excerpt

Genetic variants at chromosomal region 11q23.3, near the gene ETS1, have been associated with systemic lupus erythematosus (SLE), or lupus, in independent cohorts of Asian ancestry. Several recent studies have implicated ETS1 as a critical driver of immune cell function and differentiation, and m...

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Identifiers

PMID: 25865496
DOI: 10.1016/j.ajhg.2015.03.002
PMCID: PMC4570281

Genes

ETS1
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25865496-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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