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Article

Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 Feb 2022

Chuang Huai-Chia, Hung Wei-Ting, Chen Yi-Ming, Hsu Pu-Ming, Yen Jeng-Hsien, Lan Joung-Liang, Tan Tse-Hua

Abstract excerpt

OBJECTIVES: MAP4K3 (GLK) overexpression in T cells induces interleukin (IL)-17A production and autoimmune responses. GLK overexpressing T-cell population is correlated with severity of human systemic lupus erythematosus (SLE); however, it is unclear how GLK is upregulated in patients with SLE. METHODS: We enrolled 181 patients with SLE and 250 individuals without SLE (93 healthy controls and 157 family members of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34610951
DOI: 10.1136/annrheumdis-2021-221010
PMCID: PMC8762023

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