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Stat3 promotes IL-10 expression in lupus T cells through <i>trans-</i> activation and chromatin remodeling

3 Sept 2014

Abstract excerpt

The immune-regulatory cytokine IL-10 plays a central role during innate and adaptive immune responses. IL-10 is elevated in the serum and tissues of patients with systemic lupus erythematosus (SLE), an autoimmune disorder characterized by autoantibody production, immune-complex formation, and altered cytokine expression. Because of its B cell-promoting effects, IL-10 may contribute to autoantibody production and...

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PMID: 25187566
DOI: 10.1073/pnas.1408023111

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