Article
Reverse PCA, a systematic approach for identifying genes important for the physical interaction between protein pairs.
PLoS genetics - 1 Jan 2013
Lev Ifat, Volpe Marina, Goor Liron, Levinton Nelly, Emuna Liach, Ben-Aroya Shay
Abstract excerpt
Protein-protein interactions (PPIs) are of central importance for many areas of biological research. Several complementary high-throughput technologies have been developed to study PPIs. The wealth of information that emerged from these technologies led to the first maps of the protein interactomes of several model organisms. Many changes can occur in protein complexes as a result of genetic and biochemical...
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