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Article

Combining natural sequence variation with high throughput mutational data to reveal protein interaction sites.

PLoS genetics - 1 Feb 2015

Melamed Daniel, Young David L, Miller Christina R, Fields Stanley

Abstract excerpt

Many protein interactions are conserved among organisms despite changes in the amino acid sequences that comprise their contact sites, a property that has been used to infer the location of these sites from protein homology. In an inter-species complementation experiment, a sequence present in a homologue is substituted into a protein and tested for its ability to support function. Therefore, substitutions that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Poly(A)-Binding Proteins

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Share to Protein Structure, Tertiary

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Source

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Identifiers

PMID: 25671604
DOI: 10.1371/journal.pgen.1004918
PMCID: PMC4335499

Genes

RRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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