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Article

Whole-genome combinatorial gene fusions generate novel genes for advanced microbial trait development.

Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2026

McNay Melody M, Baffert Sabrina, Greener Alan, Schvarcz Christopher R, Mitchell B Greg, Zieler Helge

Abstract excerpt

Translational fusion of two separate genes into a compound sequence encoding a fusion protein is a key evolutionary mechanism which underpins the emergence of new protein activities, families, and architectures. In biotechnology, gene fusion is a valuable molecular evolution tool for tagging proteins of interest and for combining or altering protein activities. To broadly demonstrate and harness the...

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PMID: 41945443
DOI: 10.1073/pnas.2527695123
PMCID: PMC13079986

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