Article

A Yeast Global Genetic Screen Reveals that Metformin Induces an Iron Deficiency-Like State

2017-09-18

Abstract excerpt

We report here a simple and global strategy to map out gene functions and target pathways of drugs, toxins or other small molecules based on “homomer dynamics” Protein-fragment Complementation Assays ( hd PCA). hd PCA measures changes in self-association (homomerization) of over 3,500 yeast proteins in yeast grown under different conditions. hd PCA complements genetic interaction measurements while eliminating...

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Literature Corpus work: d350bd6e-f77a-53a1-8904-fc10a04dd8a5
DOI: 10.1101/190389

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