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Article

Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish.

Blood - 9 Jan 2014

Choorapoikayil Suma, Kers Rianne, Herbomel Philippe, Kissa Karima, den Hertog Jeroen

Abstract excerpt

Self-renewing hematopoietic stem/progenitor cells (HSPCs) produce blood cells of all lineages throughout life. Phosphatase and tensin homolog (PTEN), a tumor suppressor that antagonizes phosphatidylinositol 3-kinase (PI3K) signaling, is frequently mutated in hematologic malignancies such as bone marrow failure and leukemia. We set out to investigate whether Pten is required for hematopoiesis. Analysis of...

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Source

Identifiers

PMID: 24124088
DOI: 10.1182/blood-2013-05-501544

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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