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Article

The Role of PTEN in Myeloid Malignancies

9 Dec 2015

Abstract excerpt

PTEN deletion in the mouse and in the zebrafish highlights the essential role of this tumor suppressor in the development of myeloid malignancies, in particular acute myeloid leukemia and myeloproliferative disorders. In humans, extensive genetic sequences of myeloid malignancies did not reveal recurrent PTEN mutations and deletions. However, PTEN was shown to be functionally inactivated in several acute myeloid...

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Identifiers

PMID: 26734127
DOI: 10.4081/hr.2015.6027

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