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Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis

22 Aug 2017

Abstract excerpt

Hematopoietic stem cell transplantation (HSCT) is an important therapy for patients with a variety of hematological malignancies. HSCT would be greatly improved if patient-specific hematopoietic stem cells (HSCs) could be generated from induced pluripotent stem cells in vitro. There is an incomplete understanding of the genes and signals involved in HSC induction, migration, maintenance, and niche engraftment....

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Share to Epigenetics and DNA Methylation
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PMID: 28830909
DOI: 10.1084/jem.20171069

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