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Article

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.

Nature - 25 May 2006

Zhang Jiwang, Grindley Justin C, Yin Tong, Jayasinghe Sachintha, He Xi C, Ross Jason T, Haug Jeffrey S, Rupp Dawn, Porter-Westpfahl Kimberly S, Wiedemann Leanne M, Wu Hong, Li Linheng

Abstract excerpt

Haematopoietic stem cells (HSCs) must achieve a balance between quiescence and activation that fulfils immediate demands for haematopoiesis without compromising long-term stem cell maintenance, yet little is known about the molecular events governing this balance. Phosphatase and tensin homologue...

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Source

Identifiers

PMID: 16633340
DOI: 10.1038/nature04747

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16633340-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.PMID 16633340Read ↗

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The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic ResponseSemantic proximity Read ↗

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PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies.Semantic proximity Read ↗

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