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Article

Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion.

Genes & development - 15 Sept 2011

Perry John M, He Xi C, Sugimura Ryohichi, Grindley Justin C, Haug Jeffrey S, Ding Sheng, Li Linheng

Abstract excerpt

Although self-renewal is the central property of stem cells, the underlying mechanism remains inadequately defined. Using a hematopoietic stem and progenitor cell (HSPC)-specific conditional induction line, we generated a compound genetic model bearing both Pten deletion and β-catenin activation. These double mutant mice exhibit a novel phenotype, including expansion of phenotypic long-term hematopoietic stem...

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Source

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Identifiers

PMID: 21890648
DOI: 10.1101/gad.17421911
PMCID: PMC3185965

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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