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Article

Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice.

Cell stem cell - 7 Sept 2012

Rossi Lara, Lin Kuanyin K, Boles Nathan C, Yang Liubin, King Katherine Y, Jeong Mira, Mayle Allison, Goodell Margaret A

Abstract excerpt

Hematopoietic stem cells (HSCs) represent one of the first recognized somatic stem cell types. As such, nearly 200 genes have been examined for roles in HSC function in knockout mice. In this review, we compile the majority of these reports to provide a broad overview of the functional modules revealed by these genetic analyses and highlight some key regulatory pathways involved, including cell cycle control,...

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Identifiers

PMID: 22958929
DOI: 10.1016/j.stem.2012.08.006
PMCID: PMC3461270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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