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PTEN Tumor-Suppressor: The Dam of Stemness in Cancer

30 Jul 2019

Abstract excerpt

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human cancers, while germline PTEN mutations cause inherited syndromes that lead to increased risk of tumors. PTEN restrains tumorigenesis through different mechanisms ranging from phosphatase-dependent and independent activities, subcellular...

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PMID: 31366089
DOI: 10.3390/cancers11081076

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