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Article

PTEN is a tumor suppressor in CML stem cells and BCR-ABL–induced leukemias in mice

18 Nov 2009

Abstract excerpt

The tumor suppressor gene phosphatase and tensin homolog (PTEN) is inactivated in many human cancers. However, it is unknown whether PTEN functions as a tumor suppressor in human Philadelphia chromosome-positive leukemia that includes chronic myeloid leukemia (CML) and B-cell acute lymphoblastic leukemia (B-ALL) and is induced by the BCR-ABL oncogene. By using our mouse model of BCR-ABL-induced leukemias, we show...

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PMID: 19965668
DOI: 10.1182/blood-2009-06-228130

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