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Article

Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals.

Proceedings of the National Academy of Sciences of the United States of America - 27 Oct 2015

Zhu Helen He, Luo Xiaolin, Zhang Kaiqing, Cui Jian, Zhao Huifang, Ji Zhongzhong, Zhou Zhicheng, Yao Jufang, Zeng Lifan, Ji Kaihong, Gao Wei-Qiang, Zhang Zhong-Yin, Feng Gen-Sheng

Abstract excerpt

Previous data suggested a negative role of phosphatase and tensin homolog (Pten) and a positive function of SH2-containing tyrosine phosphatase (Shp2)/Ptpn11 in myelopoiesis and leukemogenesis. Herein we demonstrate that ablating Shp2 indeed suppressed the myeloproliferative effect of Pten loss, indicating directly opposing functions between pathways regulated by these two enzymes. Surprisingly, the Shp2 and Pten...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26460004
DOI: 10.1073/pnas.1507599112
PMCID: PMC4629356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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