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Pten regulates neural crest proliferation and differentiation during mouse craniofacial development

8 Nov 2017

Abstract excerpt

BACKGROUND: The phosphatase and tensin homolog deleted on chromosome TEN (Pten) is implicated in a broad range of developmental events and diseases. However, its role in neural crest and craniofacial development has not been well illustrated. RESULTS: Using genetically engineered mouse models, we showed that inactivating Pten specifically in neural crest cells causes malformation of craniofacial structures. Pten...

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PMID: 29115005
DOI: 10.1002/dvdy.24605

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