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Article

Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization.

The Journal of experimental medicine - 21 Oct 2013

Tesio Melania, Oser Gabriela M, Baccelli Irène, Blanco-Bose William, Wu Hong, Göthert Joachim R, Kogan Scott C, Trumpp Andreas

Abstract excerpt

The phosphatase and tumor suppressor PTEN inhibits the phosphoinositol-3-kinase (PI3K) signaling pathway and plays a key role in cell growth, proliferation, survival, and migration. Pten conditional deletion using MxCre or Scl-CreER(T) leads to splenomegaly and leukemia formation, which occurs after the relocation of normal hematopoietic stem cells (HSCs) from the bone marrow to the spleen. Unexpectedly, dormant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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Source

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Identifiers

PMID: 24127490
DOI: 10.1084/jem.20122768
PMCID: PMC3804947

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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