Article
Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: role of β-catenin/connexin43 association.
Experimental cell research - 10 Dec 2013
Talhouk Rabih S, Fares Mohamed-Bilal, Rahme Gilbert J, Hariri Hanaa H, Rayess Tina, Dbouk Hashem A, Bazzoun Dana, Al-Labban Dania, El-Sabban Marwan E
Abstract excerpt
Connexins (Cx), gap junction (GJ) proteins, are regarded as tumor suppressors, and Cx43 expression is often down regulated in breast tumors. We assessed the effect of Cx43 over-expression in 2D and 3D cultures of two breast adenocarcinoma cell lines: MCF-7 and MDA-MB-231. While Cx43 over-expression decreased proliferation of 2D and 3D cultures of MCF-7 by 56% and 80% respectively, MDA-MB-231 growth was not...
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