Article
Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication.
The Journal of biological chemistry - 9 Aug 2002
Qin Hong, Shao Qing, Curtis Heather, Galipeau Jacques, Belliveau Daniel J, Wang Taiqi, Alaoui-Jamali Moulay A, Laird Dale W
Abstract excerpt
The mechanism by which gap junction proteins, connexins, act as potent tumor suppressors remains poorly understood. In this study human breast tumor cells were found to exhibit diverse gap junction phenotypes including (a) undetectable Cx43 and no intercellular communication (HBL100); (b) low levels of Cx43 and sparse intercellular communication (MDA-MB-231); and (c) significant levels of Cx43 and moderate...
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