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Article

Reduction in gap junction intercellular communication promotes glioma migration.

Oncotarget - 10 May 2015

Aftab Qurratulain, Sin Wun-Chey, Naus Christian C

Abstract excerpt

Glioblastoma Multiforme (GBM), an aggressive form of adult brain tumor, is difficult to treat due to its invasive nature. One of the molecular changes observed in GBM is a decrease in the expression of the gap junction protein Connexin43 (Cx43); however, how a reduction in Cx43 expression contributes to glioma malignancy is still unclear. In this study we examine whether a decrease in Cx43 protein expression has...

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Identifiers

PMID: 25926558
DOI: 10.18632/oncotarget.3407
PMCID: PMC4484468

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