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Connexins Act as Tumor Suppressors in Three-dimensional Mammary Cell Organoids by Regulating Differentiation and Angiogenesis

15 Oct 2006

Abstract excerpt

Connexins are tumor suppressors, and human breast connexin 26 (Cx26) and connexin 43 (Cx43) gap junctions are often down-regulated in breast cancer. We previously showed that Cx26 and Cx43 overexpressed in MDA-MB-231 breast cancer cells inhibited tumor growth in vivo but not in two-dimensional cultures. In the current study, we show that overexpression of Cx26 or Cx43 has tumor-suppressive properties in a...

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PMID: 17047050
DOI: 10.1158/0008-5472.can-05-4302

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Connexins Act as Tumor Suppressors in Three-dimensional Mammary Cell Organoids by Regulating Differentiation and AngiogenesisPMID 17047050Read ↗

Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism.Semantic proximity Read ↗

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Connexin26-mediated gap junctional communication reverses the malignant phenotype of MCF-7 breast cancer cells.Semantic proximity Read ↗

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Gap junction proteins connexin32 and connexin43 partially acquire growth-suppressive function in HeLa cells by deletion of their C-terminal tails.Semantic proximity Read ↗

Targeting the Cx26/NANOG/Focal Adhesion Kinase Complex via Cell-Penetrating Peptides in Triple-Negative Breast CancersSemantic proximity Read ↗

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Connexin 43 maintains tissue polarity and regulates mitotic spindle orientation in the breast epitheliumSemantic proximity Read ↗

Connexin 43 reverses malignant phenotypes of glioma stem cells by modulating E-cadherin.Semantic proximity Read ↗

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Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/FAK axis.Semantic proximity Read ↗

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