Article
Immortalized connexin43 knockout cell lines display a subset of biological properties associated with the transformed phenotype.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1997
Martyn K D, Kurata W E, Warn-Cramer B J, Burt J M, TenBroek E, Lau A F
Abstract excerpt
Immortalized cells from embryonic connexin43 knockout mice (Cx43-/-) and homozygous littermates (Cx43+/+) were cloned and characterized to determine whether the absence of Cx43 function would induce observable phenotypic changes. Cells of the Cx43+/+ clones expressed Cx43 and engaged in gap junct...
Topics
- Animals
- Cell Division
- Cell Line, Transformed
- Clone Cells
- Connexin 43
- Gap Junctions
- Mice
- Mice, Knockout
- Phenotype
- RNA
- Time Factors
- Transfection