Article
Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jun 1995
Chen S C, Pelletier D B, Ao P, Boynton A L
Abstract excerpt
Communication between adjacent cells through gap junctions is believed to be involved in the regulation of cell proliferation. This stems in part from the observation that transfection and overexpression of connexin (cx) 32 or cx43 genes into neoplastic cells lead to normalization of growth and d...
Topics
- Animals
- Cell Division
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Connexin 43
- Contact Inhibition
- Cricetinae
- Cyclin-Dependent Kinases
- Cyclins
- Dogs
- Enzyme Induction
- G1 Phase
- Gap Junctions
- Gene Expression Regulation, Neoplastic
- Kidney
- Liver
- Neoplasm Proteins
- Phenotype