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Article

Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jun 1995

Chen S C, Pelletier D B, Ao P, Boynton A L

Abstract excerpt

Communication between adjacent cells through gap junctions is believed to be involved in the regulation of cell proliferation. This stems in part from the observation that transfection and overexpression of connexin (cx) 32 or cx43 genes into neoplastic cells lead to normalization of growth and decrease their tumorigenicity. The molecular mechanism(s) responsible for this phenomenon has not been characterized. We...

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Source

Identifiers

PMID: 7669722

Genes

CDK2
CDK4
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases.PMID 7669722Read ↗

Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: role of β-catenin/connexin43 association.Semantic proximity Read ↗

Localization and function of the connexin 43 gap-junction protein in normal and various oncogene-expressing rat liver epithelial cells.Semantic proximity Read ↗

Connexins as targets for cancer chemoprevention and chemotherapy.Semantic proximity Read ↗

Neoplastic phenotype of gap-junctional intercellular communication-deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32.Semantic proximity Read ↗

Immortalized connexin43 knockout cell lines display a subset of biological properties associated with the transformed phenotype.Semantic proximity Read ↗

A connexin 43 mutant lacking the carboxyl cytoplasmic domain inhibits both growth and motility of mouse 3T3 fibroblasts.Semantic proximity Read ↗

Connexin43 inhibits the oncogenic activity of c-Src in C6 glioma cells.Semantic proximity Read ↗

Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication.Semantic proximity Read ↗

Restoration of gap-junctional intercellular communication in a communication-deficient rat liver cell mutant by transfection with connexin 43 cDNA.Semantic proximity Read ↗

Connexins: junctional and non-junctional modulators of proliferationSemantic proximity Read ↗

Disrupted traffic of connexin 43 in human testicular seminoma cells: overexpression of Cx43 induces membrane location and cell proliferation decreaseSemantic proximity Read ↗

Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43).Semantic proximity Read ↗

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