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Article

Connexin 43 maintains tissue polarity and regulates mitotic spindle orientation in the breast epithelium

16 Apr 2019

Abstract excerpt

ABSTRACT Cell–cell communication is essential for tissue homeostasis, but its contribution to disease prevention remains to be understood. We demonstrate the involvement of connexin 43 (Cx43, also known as GJA1) and related gap junction in epithelial homeostasis, illustrated by polarity-mediated cell cycle entry and mitotic spindle orientation (MSO). Cx43 localization is restricted to the apicolateral membrane of...

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PMID: 30992345
DOI: 10.1242/jcs.223313

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