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Article

Connexin 43 reverses malignant phenotypes of glioma stem cells by modulating E-cadherin.

Stem cells (Dayton, Ohio) - 1 Feb 2012

Yu Shi-Cang, Xiao Hua-Liang, Jiang Xue-Feng, Wang Qing-Liang, Li Yan, Yang Xiao-Jun, Ping Yi-Fang, Duan Jiang Jie, Jiang Jian-Yong, Ye Xian-Zong, Xu Sen-Lin, Xin Yang-Hong, Yao Xiao-Hong, Chen Jian-Hong, Chu Wei-Hua, Sun Wei, Wang Bing, Wang Ji Ming, Zhang Xia, Bian Xiu-Wu

Abstract excerpt

Malfunctioned gap junctional intercellular communication (GJIC) has been thought associated with malignant transformation of normal cells. However, the role of GJIC-related proteins such as connexins in sustaining the malignant behavior of cancer stem cells remains unclear. In this study, we obtained tumorspheres formed by glioma stem cells (GSCs) and adherent GSCs and then examined their GJIC. All GSCs showed...

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Identifiers

PMID: 22131169
DOI: 10.1002/stem.1685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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