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Article

Phosphorylation of the N- and C-terminal UPF1 domains plays a critical role in plant nonsense-mediated mRNA decay.

The Plant journal : for cell and molecular biology - 1 Dec 2013

Kerényi Farkas, Wawer Izabela, Sikorski Pawel J, Kufel Joanna, Silhavy Dániel

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is an essential quality control system that degrades aberrant transcripts containing premature termination codons and regulates the expression of several normal transcripts. Targets for NMD are selected during translational termination. If termination is slow, the UPF1 NMD factor binds the eRF3 protein of the termination complex and then recruits UPF2 and UPF3. Consequently, the...

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Source

Identifiers

PMID: 24118551
DOI: 10.1111/tpj.12346

Genes

UPF1
SMG7
UPF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Phosphorylation of the N- and C-terminal UPF1 domains plays a critical role in plant nonsense-mediated mRNA decay.PMID 24118551Read ↗

UPF1 is required for nonsense-mediated mRNA decay (NMD) and RNAi in Arabidopsis.Semantic proximity Read ↗

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.Semantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

Nonsense-Mediated RNA Decay Factor UPF1 Is Critical for Posttranscriptional and Translational Gene Regulation in Arabidopsis.Semantic proximity Read ↗

Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival.Semantic proximity Read ↗

Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StorySemantic proximity Read ↗

A highly conserved region essential for NMD in the Upf2 N-terminal domain.Semantic proximity Read ↗

Arabidopsis plants having defects in nonsense-mediated mRNA decay factors UPF1, UPF2, and UPF3 show photoperiod-dependent phenotypes in development and stress responses.Semantic proximity Read ↗

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.Semantic proximity Read ↗

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Semantic proximity Read ↗

Characterization of the mIF4G domains in the RNA surveillance protein Upf2Semantic proximity Read ↗

SMG1:SMG8:SMG9-complex integrity maintains robustness of nonsense-mediated mRNA decaySemantic proximity Read ↗

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