Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data.

doi:10.1002/hep.26767

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Article

Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data.

Hepatology (Baltimore, Md.) - 1 Jun 2014

Trépo Eric, Nahon Pierre, Bontempi Gianluca, Valenti Luca, Falleti Edmondo, Nischalke Hans-Dieter, Hamza Samia, Corradini Stefano Ginanni, Burza Maria Antonella, Guyot Erwan, Donati Benedetta, Spengler Ulrich, Hillon Patrick, Toniutto Pierluigi, Henrion Jean, Franchimont Denis, Devière Jacques, Mathurin Philippe, Moreno Christophe, Romeo Stefano, Deltenre Pierre

Abstract excerpt

UNLABELLED: The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries. Although several clinical factors have been identified, many individuals never develop HCC, suggesting a genetic susceptibility. However, to date, only a few single-nucleotide polymorphisms have been reproducibly shown to be linked to HCC onset. A variant (rs738409 C>G, encoding for p.I148M) in the PNPLA3 gene is...

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PMID: 24114809
DOI: 10.1002/hep.26767

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PNPLA3

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Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data.PMID 24114809Read ↗

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