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Article

PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence.

Liver international : official journal of the International Association for the Study of the Liver - 1 Sept 2011

Falleti Edmondo, Fabris Carlo, Cmet Sara, Cussigh Annarosa, Bitetto Davide, Fontanini Elisabetta, Fornasiere Ezio, Bignulin Sara, Fumolo Elisa, Bignulin Eleonora, Pirisi Mario, Toniutto Pierluigi

Abstract excerpt

BACKGROUND AND AIM: The PNPLA3 rs738409 C>G polymorphism has been found to be strongly associated with non-alcoholic fatty liver disease and with alcoholic liver disease. Whether the PNPLA3 rs738409 polymorphism could be a risk factor for the development of hepatocellular carcinoma (HCC) in cirrhosis patients is unknown. METHODS: This study included 483 (344 males) consecutive Italian patients of Caucasian...

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Share to Carcinoma, Hepatocellular
Share to Chi-Square Distribution
Share to Fatty Liver
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Share to Liver Cirrhosis
Share to Liver Cirrhosis, Alcoholic
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Source

Identifiers

PMID: 21745286
DOI: 10.1111/j.1478-3231.2011.02534.x

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence.PMID 21745286Read ↗

PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis.Semantic proximity Read ↗

The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.Semantic proximity Read ↗

Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data.Semantic proximity Read ↗

Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease.Semantic proximity Read ↗

Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma.Semantic proximity Read ↗

The PNPLA3 rs738409 C > G polymorphism is associated with the risk of progression to cirrhosis in NAFLD patients.Semantic proximity Read ↗

Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians.Semantic proximity Read ↗

PNPLA3 rs738409 I748M is associated with steatohepatitis in 434 non-obese subjects with hepatitis C.Semantic proximity Read ↗

Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease.Semantic proximity Read ↗

The impact of the PNPLA3 rs738406 C>G polymorphism on hepatocellular carcinoma risk in Brazilian patients with chronic hepatitis C and advanced fibrosis.Semantic proximity Read ↗

Association of PNPLA3 rs738409 polymorphism with liver steatosis but not with cirrhosis in patients with HBV infection: Systematic review with meta-analysis.Semantic proximity Read ↗

Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis.Semantic proximity Read ↗

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