Article
The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.
PloS one - 1 Jan 2011
Nischalke Hans Dieter, Berger Cordula, Luda Carolin, Berg Thomas, Müller Tobias, Grünhage Frank, Lammert Frank, Coenen Martin, Krämer Benjamin, Körner Christian, Vidovic Natascha, Oldenburg Johannes, Nattermann Jacob, Sauerbruch Tilman, Spengler Ulrich
Abstract excerpt
BACKGROUND: An isoleucine>methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis. Here, we studied whether the PNPLA3 rs738409 polymorphism also affects predisposition to hepatocellular carcinoma (HCC). METHODS: We compared distributions of PNPLA3 genotypes in 80 and 81 Caucasian patients with alcoholic...
Read the complete abstract on PubMed