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Article

PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis.

Journal of hepatology - 1 Feb 2013

Guyot Erwan, Sutton Angela, Rufat Pierre, Laguillier Christelle, Mansouri Abdellah, Moreau Richard, Ganne-Carrié Nathalie, Beaugrand Michel, Charnaux Nathalie, Trinchet Jean-Claude, Nahon Pierre

Abstract excerpt

BACKGROUND & AIMS: Several studies have reported an association between the genetic variant rs738409 (G) in the PNPLA3 gene and the risk of cirrhosis in various liver diseases. Our purpose was to assess the influence of this polymorphism on the risk of hepatocellular carcinoma (HCC) occurrence in two distinct longitudinal cohorts of patients with cirrhosis as well as its possible usefulness in HCC-risk model...

Topics

Carcinoma, Hepatocellular
Female
Follow-Up Studies
Genotype
Hepatitis C, Chronic
Humans
Incidence
Kaplan-Meier Estimate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipase

Liver Cirrhosis

Liver Cirrhosis, Alcoholic

Liver Neoplasms

Male

Membrane Proteins

Middle Aged

Models, Statistical

Multivariate Analysis

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 23069476
DOI: 10.1016/j.jhep.2012.09.036

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23069476-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis.PMID 23069476Read ↗

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