Article
Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma.
Journal of hepatology - 1 Jul 2014
Liu Y-L, Patman G L, Leathart J B S, Piguet A-C, Burt A D, Dufour J-F, Day C P, Daly A K, Reeves H L, Anstee Q M
Abstract excerpt
BACKGROUND & AIMS: Subtle inter-patient genetic variation and environmental factors combine to determine disease progression in non-alcoholic fatty liver disease (NAFLD). Carriage of the PNPLA3 rs738409 c.444C >G minor allele (encoding the I148M variant) has been robustly associated with advanced NAFLD. Although most hepatocellular carcinoma (HCC) is related to chronic viral hepatitis or alcoholic liver disease,...
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