Article
Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: risk and prognosis prediction.
Molecular carcinogenesis - 1 Nov 2013
Hassan Manal M, Kaseb Ahmed, Etzel Carol J, El-Serag Hashem, Spitz Margaret R, Chang Ping, Hale Katherine S, Liu Mei, Rashid Asif, Shama Mohamed, Abbruzzese James L, Loyer Evelyne M, Kaur Harmeet, Hassabo Hesham M, Vauthey Jean-Nicolas, Wray Curtis J, Hassan Basmah S, Patt Yehuda Z, Hawk Ernest, Soliman Khalid M, Li Donghui
Abstract excerpt
Nonalcoholic fatty liver disease (NAFLD) is an emerging epidemic with high prevalence in Western countries. Genome-wide association studies had reported that a variation in the patatin-like phospholipase domain containing 3 (PNPLA3) gene is associated with high susceptibility to NAFLD. However, the relationship between this variation and hepatocellular carcinoma (HCC) has not been well established. We...
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