PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease.

doi:10.1016/j.dld.2012.12.006

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Article

PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Aug 2013

Valenti Luca, Dongiovanni Paola, Ginanni Corradini Stefano, Burza Maria Antonella, Romeo Stefano

Abstract excerpt

Hepatocellular carcinoma (HCC) is highly associated with chronic liver disease. The rs738409 genetic variant in the patatin-like phospholipase domain-containing 3 (PNPLA3, adiponutrin) gene has been implicated as a genetic determinant of the entire spectrum of liver diseases, ranging from steatosis, chronic hepatitis, cirrhosis and ultimately to HCC. In this review, first we will examine the current genetic...

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Identifiers

PMID: 23333103
DOI: 10.1016/j.dld.2012.12.006

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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