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Article

PNPLA3 I148M and Hepatocellular Carcinoma.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2025

Tavaglione Federica, Pennisi Grazia, Pelusi Serena

Abstract excerpt

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. With the widespread implementation of HBV vaccination and the availability of highly effective antiviral therapies, the incidence of metabolic dysfunction-associated steatotic liver disease (MASLD)-related HCC has proportionally increased. Notably, up to 20%-30% of MASLD-related HCC cases develop in the absence of overt...

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Source

Identifiers

PMID: 40029157
DOI: 10.1111/liv.70051

Genes

PNPLA3

Variants

Provenance

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Related research

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PNPLA3 I148M and Hepatocellular Carcinoma.PMID 40029157Read ↗

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Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD.Semantic proximity Read ↗

Global Epidemiological Impact of PNPLA3 I148M on Liver Disease.Semantic proximity Read ↗

Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data.Semantic proximity Read ↗

Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B.Semantic proximity Read ↗

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Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C.Semantic proximity Read ↗

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