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PNPLA3 Genotype and Clinical Factors Impact Hepatocellular Carcinoma Risk: Findings From a Prospective Cohort Study.

Alimentary pharmacology & therapeutics - 1 May 2026

Huang Daniel Q, Zhang Zhongjie, Dorajoo Rajkumar, Khor Chiea Chuen, Pham Yen Thi-Hai, Wang Renwei, Behari Jaideep, Yuan Jian-Min, Koh Woon-Puay, Luu Hung N

Abstract excerpt

BACKGROUND AND AIMS: PNPLA3 variants are associated with increased hepatocellular carcinoma (HCC) risk. We examined the association between a combination of the PNPLA3 I148M genotype and clinical risk factors with HCC risk using data from a large, ongoing, population-based, prospective cohort study, the Singapore Chinese Health Study. APPROACH AND RESULTS: This study included 24,979 participants (54.2% female)....

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Identifiers

PMID: 41527281
DOI: 10.1111/apt.70532

Genes

PNPLA3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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