The impact of the PNPLA3 rs738406 C>G polymorphism on hepatocellular carcinoma risk in Brazilian patients with chronic hepatitis C and advanced fibrosis.

doi:10.1016/j.clinsp.2025.100797

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Article

The impact of the PNPLA3 rs738406 C>G polymorphism on hepatocellular carcinoma risk in Brazilian patients with chronic hepatitis C and advanced fibrosis.

Clinics (Sao Paulo, Brazil) - 1 Jan 2025

Maccali Claudia, Pereira Isabel Veloso Alves, Saud Lisa Rodrigues da Cunha, Alencar Regiane Saraiva de Souza Melo, Oliveira Arthur Ivan Nobre, Stefano Jose Tadeu, Gouvea Michele Soares Gomes, Etto Joyce Matie Kinoshita da Silva, Herman Paulo, Pinho João Renato Rebello, Pinheiro Rafael Soares Nunes, Andraus Wellington, D'Albuquerque Luiz Augusto Carneiro, Pessoa Mario Guimarães, Chagas Aline Lopes, de Oliveira Claudia Pinto Marques Souza

Abstract excerpt

INTRODUCTION: The PNPLA3 rs738409 C>G polymorphism has been associated with fibrosis and steatosis in Chronic Hepatitis C (CHC) patients. However, its impact on Hepatocellular Carcinoma (HCC) development in this population remains unclear. This study aimed to evaluate the impact of the PNPLA3 polymorphism on the risk of HCC development in CHC patients in Brazil. METHODS: This retrospective case-control study...

Topics

Humans
Male
Carcinoma, Hepatocellular
Female
Lipase
Hepatitis C, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Liver Neoplasms

Membrane Proteins

Case-Control Studies

Retrospective Studies

Liver Cirrhosis

Brazil

Risk Factors

Genetic Predisposition to Disease

Adult

Genotype

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41092564
DOI: 10.1016/j.clinsp.2025.100797
PMCID: PMC12550332

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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