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Article

MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2004

Curtin Karen, Bigler Jeannette, Slattery Martha L, Caan Bette, Potter John D, Ulrich Cornelia M

Abstract excerpt

5,10-methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism, diverting metabolites toward methylation reactions or nucleotide synthesis. Using data from an incident case-control study (1608 cases and 1972 controls) we investigated two polymorphisms in the MTHFR gene, C677T and A1298C, and their associations with risk of colon cancer. All of the combined genotypes were evaluated...

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Source

Identifiers

PMID: 14973104
DOI: 10.1158/1055-9965.epi-03-0083

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer.PMID 14973104Read ↗

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